COPD
Conditions
Interventions
Phlegm wet physique healthy people:N/A
Phlegm wet constitution chronic bronchitis:N/A
Phlegm wet constitution chronic obstructive pulmonary disease:N/A
Sponsors
Dongzhimen Hospital, Beijing University of Chinese Medicine
Eligibility
Sex/Gender
All
Age
40 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1: Age between 40-75 years old, 100 patients with chronic bronchitis with phlegm wet constitution, 100 patients with COPD, regardless of gender. Clinical signs and symptoms of typical chronic obstructive pulmonary disease: (1) Cough: aggravated in the morning and pronounced in the evening. (2) Sputum cough: mucous sputum, purulent sputum when infected. (3) Shortness of breath: gradually aggravated, obvious after activity. (4) Wheezing: Some patients have onset. Prolonged expiratory or dry rales on exhalation. As the disease progresses, hyperbloated chest, increased anteroposterior diameter, limited diaphragmatic movement, decreased breath sounds, and distant heart sounds occur. In addition, both lung bases or lung fields may have wet and/or dry sounds. In advanced patients, dyspnea is aggravated, and the body is often tilted forward, and the neck and shoulder auxiliary respiratory muscles participate in breathing exercises. Breathing is often pursed lips and exhaled. There are cyanosis of the lips and signs of right heart failure. Clinical symptoms and signs of typical chronic bronchitis: 1. Clinical chronic or repeated cough, sputum production or accompanied by wheezing, at least 3 months of onset every year, and 2 consecutive years or more. 2. If the onset lasts less than 3 months per year, and there is a clear objective examination basis (such as X-ray, lung function, etc.) can also be diagnosed. 3. Exclude cough, sputum or wheezing caused by other heart and lung diseases (such as tuberculosis, pneumoconiosis, bronchial asthma, bronchiectasis, lung cancer, heart disease, cardiac insufficiency, chronic rhinitis, etc.). Meet the above clinical diagnostic criteria for chronic bronchitis and chronic obstructive pulmonary disease: informed consent of the patient and sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1: (1) Patients with other cardiopulmonary diseases, autoimmune diseases or chronic wasting diseases, (2) Diabetic patients with uncontrolled blood sugar; (3) Patients with primary diseases such as liver, kidney and hematopoietic system; (4) Patients with epilepsy, psychosis, cerebrovascular disease, active tuberculosis, etc.; (5) pregnant and lactating women; (6) Patients with chronic infectious diseases and infectious diseases in the respiratory tract and other parts in the past 2 weeks. Patients who have taken medication before bedtime. 2: People with severe food allergies; Incomplete collection of clinical information.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| UPLC-MS metabolomics in fasting blood samples;Lung function;Traditional Chinese Medicine phlegm wet body quality table;mMRC score; | — |
Countries
China
Contacts
Public ContactLI Jie
Dongzhimen Hospital, Beijing University of Chinese Medicine
Outcome results
None listed