Gynecopathy
Conditions
Interventions
Experimental group (Esketamine group ):Esketamine is administered an 0.25mg/kg prior to deemectomy after anesthesia and then maintained at 0.1mg/kg/h.The drug was discontinued about 15minutes before t
Control group :Normal saline was administered an 0.25mg/kg prior to deemectomy after of anesthesia and then maintained at 0.1mg/kg/h.The drug is discontinued about 15minutes before the end of surgery.
Sponsors
Peking University Shenzhen Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Age 18-65 years ,2.ASA physical status I-?,3.18.5=BMI=30,4.Schduled for laparoscopic surgery under general anesthesia,including laparoscopic total hysterectomy,myomectomy,double adnexectomy,and ovarian cyst removel(except for patients with malignant tumors),5.inforemed consent can be signed.
Exclusion criteria
Exclusion criteria: 1.Diagnosed mental illness,2.A history of chronic pain or opioid abuse before surgery,3.Allergy to esketamine and flubiprofen ester,4.Patients with contraindicated used of esketamine,5.Patients with contraindicated used of flubiprofen ester,6.pregnacy or lactation,7.History of alcohol addiction,8.Patients with malignant tumors,9.Refuse to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The global score Quality of Recovery-40 Scale(QoR-40) at 24 hours after surgery); | — |
Secondary
| Measure | Time frame |
|---|---|
| Dosage of sedative analgesic drugs during operative;Acute pain score at immediately,6,12,and 24 hours after surgery;Dosage of postoperative analgesics;Consumption of vasoactive agents;postoperative nausea and vommiting score;duration of anesthesia and surgery;Awakening time; | — |
Countries
China
Contacts
Public ContactWenli He
Peking University Shenzhen Hospital
Outcome results
None listed