Knee arthritis
Conditions
Interventions
Test group:Application of Betamethasone
Control group:Application of normal saline
Sponsors
Department of Knee Joints, Xi'an HongHui Hospital
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Adult knee osteoarthritis patients receiving the first unilateral TKA in Xi 'an Honghui Hospital; 2. Adult patients with American Society of Anesthesiologists (ASA) functional status I-III and aged 50-80 years old gave informed consent to participate in this study.
Exclusion criteria
Exclusion criteria: 1. Cardiovascular impairment (New York Heart Association rating > 2); 2. Renal function (glomerular filtration rate B); Poor diabetes control (DM; HbA1c > 7.5%); 4. Allergy to any investigational drug; 5. Have taken any strong opioids in the past week or received systemic corticosteroid therapy within 3 months before surgery; 6. Alcohol dependence or substance abuse, such as opioid dependence (morphine, fentanyl, or oxycodone); 7. Cognitive impairment; 8. Effects of psychological and neurological impairment on pain perception; 9. Patients who stopped intravenous (IV) controlled analgesia; 10. Body mass Index (BMI) > 35 kg/m2; 11. Previous history of PONV/ motion sickness; 12. All subjects who have language impairments, are unable or unwilling to provide informed consent, or are unable to comply with the requirements of the study, are deemed by the investigator to be unsuitable for participation in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Nausea level;Vomiting frequency; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain level;knee motion;C-reactive protein;erythrocyte sedimentation rate;Interleukin-6; | — |
Countries
China
Contacts
Public ContactXiaobo Sun
Xi'an Honghui Hospital
Outcome results
None listed