Prostate Cancer
Conditions
Interventions
Case series:N/A
Sponsors
Third Affiliated Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
Male
Age
40 Years to No maximum
Inclusion criteria
Inclusion criteria: Part 1: One of the following cases occurs in men aged over 40 years: 1. Symptoms: repeated macroscopic hematuria, difficulty in urination, etc.; 2. Sign: suspected nodules detected by the prostate digital rectal examination(DRE); 3. PSA: PSA value more than 3 ng/ml, fPSA/tPSA value less than 0.16; 4. Transrectal ultrasonography(TRUS): an internal structural disturbance or low echo area in the prostate; 5. Willing to accept research and sign research voluntary books. Part 2: Case inclusion criteria (based on EUA prostate cancer treatment guidelines 2016): 1. Patients with low-risk prostate cancer (T1b - T2c, N0, M0), and life expectancy was greater than 10 years; 2. Patients with high risk of prostate cancer (T3a, N0, M0), and life expectancy is greater than 10 years; 3. Patients with locally advanced high risk of prostate cancer (cT3b–T4, N0 or any T, N1, M0), and life expectancy is greater than 10 years; 4. The tumor staging was lower than T1a, but patients had a strong desire to operate and the life expectancy expected to live longer; 5. Willing to accept research and sign research voluntary books.
Exclusion criteria
Exclusion criteria: Part 1: 1. Acute urinary tract infection and intestinal infection; 2. Recent factors such as urinary catheterizing, bladder microscopy or prostate massage which have affected the elevated PSA; 3. Refuse to follow up. Part 2: 1. The previous history of bladder neck, urethra, and pelvic surgery; 2. Accompany with severe blood coagulation dysfunction, difficult to control high blood pressure or diabetes, severe heart, lung, liver, kidney and other important organ dysfunction, or other serious internal medical disease, or life expectancy less than 10 years; 3. Accompany with other tumors, oral immune inhibitors, and blood disease; 4. Unwilling to participate in the research or the follow-up address is unclear.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PSA;Prostate volume;Pathological results;Gleason score;Tumor stage;Adjuvant therapy;Biochemical recurrence;Tumor metastasis; | — |
Secondary
| Measure | Time frame |
|---|---|
| Overall survival;quality of life;adverse event;vital signs;Laboratory indicators; | — |
Countries
China
Contacts
Public ContactLai Wenjie
Third Affiliated Hospital of Sun Yat-sen University
Outcome results
None listed