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The Effect of Low-Dose Remifentanil Infusion on Emergence Agitation and Postoperative Cognitive Function after General Anesthesia

The Effect of Low-Dose Remifentanil Infusion on Emergence Agitation and Postoperative Cognitive Function after General Anesthesia

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300072522
Enrollment
Unknown
Registered
2023-06-15
Start date
2023-07-01
Completion date
Unknown
Last updated
2023-06-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Emergent Agitation

Interventions

Control Group :The first agitation is controlled with intravenous propofol 1 mg / kg immediately and NS IVVP.
Test Group:The first agitation is controlled with intravenous propofol 1 mg / kg immediately and remifentanil IVVP 0.1 µ g /( kg·min).

Sponsors

The First Affiliated Hospital, Zhejiang University School of Medicine
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1) After elective general anesthesia surgery, EA in PACU (Ricker = 6 points); 2) 18 years = age = 75 years; 3) ASA I-III.

Exclusion criteria

Exclusion criteria: 1) Patients who are unable to communicate normally before surgery; 2) Patients with mental illness who take psychotropic drugs for a long time; 3) Central nervous system disease (such as dementia and Parkinson's disease); 4) Patients with a history of allergy or addiction to opioid drugs; 5) Patients who are allergic to propofol.

Design outcomes

Primary

MeasureTime frame
Recurrent emergence agitation;

Secondary

MeasureTime frame
Riker sedation-agitation score after treatment at different time points.;Patient's vital signs at different time points;Time to remove the tracheal tube;Awake quality after general anaesthesia;Comfort Scale at extubation;VAS and rescue medication;

Countries

China

Contacts

Public ContactYongxing Yao

The First Affiliated Hospital, Zhejiang University School of Medicine

yao_yongxing@163.com+86 136 5666 8373

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026