Induction of general anesthesia
Conditions
Interventions
Experimental group:esketamine introduction
control group:sufentanil introduction
Sponsors
First Affiliated Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
20 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1) Age 20~65 years old, BMI 18~28 kg/m2; 2) ASA grading II~III; 3) Sign informed consent before surgery;
Exclusion criteria
Exclusion criteria: 1) Have a history of mental illness and endocrine system diseases; 2) Allergy to opioids or other narcotics; 3) History of severe heart and lung diseases; 4) Have a history of substance abuse or alcohol abuse; 5) Patients at serious risk of increased blood pressure or intracranial pressure; 6) Patients with poorly controlled or untreated hypertension (arterial hypertension, resting systolic / diastolic blood pressure exceeding 180 / 100 mmHg); 7) preeclampsia and eclampsia; 8) Patients with hyperthyroidism who are untreated or undertreated.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in average blood flow velocity of the middle cerebral artery before intubation compared to before induction; | — |
Secondary
| Measure | Time frame |
|---|---|
| blood pressure;heart rate;Middle cerebral artery systolic blood flow velocity;Diastolic blood flow velocity of middle cerebral artery;Mean blood flow velocity of the middle cerebral artery; | — |
Countries
china
Contacts
Public ContactLi qiying
First Affiliated Hospital of Chongqing Medical University
Outcome results
None listed