allergic rhinitis
Conditions
Interventions
Dual SLIT group:Dual SLIT treatment with Artemisia Annua Allergens Sublingual Immunotherapy Drops and Dermatophagoides Farinae Drops
Control group:Only receive medication treatment
Sponsors
First Hospital of Shanxi Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: ?Ranges from 18 to 60 years old (including 18 and 60 years old), both male and female; ?Patients manifested obvious nasal symptoms of Artemisia pollen allergic rhinitis during at least the previous two Artemisia pollen seasons, as well as perennial nasal symptoms even outside the Artemisia pollen season, with or without allergic conjunctivitis; ?Patient tested positive for serum allergen-specitific IgE test or skin prick test against both Artemisia annua/Artemisia vulgaris and Dermatophagoides farina/ Dermatophagoides pteronyssinus, with the level > class 2 or “++”; ?Patients can understand and sign the informed consent; ?Patients can comply with the plan.
Exclusion criteria
Exclusion criteria: ?Patients with any history of severe systemic allergic reactions or eosinophilic esophagitis prior to screening evaluation; ?Diagnosed with a history of moderate or severe asthma or had evidence that FEV1 was less than 70% estimated within 2 years prior to enrollment; ?Patients were being treated with ß-blockers (both systemic and topical) or angiotensin converting enzyme (ACE) inhibitors; ?Pregnant or lactating women; ?Patients with a history of immunosuppressive diseases (such as HIV infection), malignant tumors, autoimmune diseases, tuberculosis, cardiovascular insufficiency, or serious diseases of other organ systems as determined by researchers; ?Any other circumstances deemed unsuitable for participation in the trial by the assessment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total nasal symptoms score;Total medication score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Total conjunctivitis symptoms score;Visual analog sacle;Symptom improvement assessment; | — |
Countries
China
Contacts
Public ContactYan Feng
First Hospital of Shanxi Medical University
Outcome results
None listed