osteoarthritis
Conditions
Interventions
Research group: Loxoprofen Sodium Cataplasm
Control group:Flubiprofen Cataplasm
Sponsors
Department of Orthopedics, the Second Affiliated Hospital of Xi 'an Jiaotong University
Eligibility
Sex/Gender
All
Age
40 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) The subject voluntarily agrees to participate in the study and signs a written informed consent; (2) Age 40-75 years old, male and female; (3) Diagnosed with osteoarthritis after clinical diagnosis; (4) The affected joints had pain intensity of =4cm and <7 points on the baseline WOMAC scale [visual analog scale (VAS)] within the last 48 hours (the side with more severe pain was selected on both sides), and the pain was sustained and stable in intensity within 1 week; (5) No history of bleeding, asthma, severe cardiac, hepatic and renal insufficiency, or allergy to non-steroidal drugs; (6) The study/control drugs used by the patient were in the drug list specified in this study.
Exclusion criteria
Exclusion criteria: (1) Patients with hemorrhagic diseases; (2) patients with bronchial asthma; (3) Patients with severe heart, liver and kidney insufficiency; Alanine aminotransferase (ALT), aspartate aminotransferase (AST) more than 2 times the normal value, serum creatinine (Cr) more than the normal value; (4) Pregnant and lactating women or women of childbearing age who are preparing to become pregnant; (5) known allergy to NSaids; (6) Patients who have participated in clinical studies of other drugs within 1 month; Other concomitant diseases or complications that may interfere with the efficacy observation (skin damage, infection; Rash)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total response rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| VAS pain score;WOMAC score;Knee Lysholm score; | — |
Countries
China
Contacts
Public ContactYang Pei
The Second Affiliated Hospital of Xi 'an Jiaotong University
Outcome results
None listed