Parkinson's disease
Conditions
Interventions
Treatment Group:Guizhilongmu Prescription combined with Shudipingchan Prescription
Control Group:The Mimic Agent of Guizhilongmu Prescription combined with Shudipingchan Prescription
Sponsors
Longhua Hospital affiliated to Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: ? Age 30-80 years old, both sexes; ? Meet The Movement Disorder Society (MDS) 2015 revised diagnostic criteria for primary Parkinson's disease; ? Hoehn-Yahr stage =3; ? The Chinese University of Hong Kong rapid eye movement Sleep Behavior Disorder Scale (RBDQ-HK) =17 points ? At least one of the following symptoms: fear of cold and heat; Constipation or diarrhoea; ? For those already on anti-Parkinsonian therapy (levodopa agents, dopamine agonists, monoamine oxidase inhibitors, catechol-O-methyltransferase inhibitors, anticholinergic drugs, etc.), the dose of anti-parkinsonian drugs was required to be relatively stable for at least 3 months before this clinical trial; And no clear plan to change the current treatment regimen in the next 3 months; ? Voluntary participation and signed informed consent.
Exclusion criteria
Exclusion criteria: ? Patients with Parkinson's disease syndrome or Parkinson's disease plus syndrome; ? Active depression or psychosis and/or antidepressant or antipsychotic medication; ? Sequelae of severe stroke and diseases of heart, lung, liver, kidney and other systems; ? History of drug abuse or alcohol abuse; ? Patients who are participating in other clinical studies or have participated in other clinical studies within the previous 30 days.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| RBD Questionnaire-HongKong(RBDQ-HK); | — |
Secondary
| Measure | Time frame |
|---|---|
| Unified Parkinson’s Disease Rating Scale, UPDRS;SCOPA-AUT;Hamilton Anxiety Scale, HAMA;Hamilton Depression Scale, HAMD;Parkinson's disease questionnaire-39, PDQ-39;Parkinson's Disease Sleep Scale, PDSS;Polysomnogram, PSG; | — |
Countries
China
Contacts
Public ContactYou Wu
Longhua Hospital affiliated to Shanghai University of Traditional Chinese Medicine
Outcome results
None listed