Cardiac valvular surgery
Conditions
Interventions
Propofol group:TCI propofol 1.8ug/ml (initial Ce 1.0 ug/ml, with graded target control in 0.3 ug/ml increments to 1.8-2.0ug/ml each time)
Ciprofol group:Intravenous injection of 0.4mg/kg of ciprofol
Sponsors
The First Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Age
45 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1) Signed informed consent form; 2) Patients undergoing elective heart valve replacement surgery; 3) Age 45-65 years; 4) ASA class II-III;
Exclusion criteria
Exclusion criteria: 1)History of heart attack or unstable angina attack within 3 months 2) history of stroke within 3 months; 3) EF values <40%; 4) those with unstable mental status and mental illness 5) those predicted to have or have had a difficult airway or patients with anticipated delayed extubation preoperatively 6) Those with established/suspected abuse of narcotic sedative analgesics; 7) Those with contraindications to the test drug and other narcotic drugs;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Area under the mean arterial pressure threshold; | — |
Secondary
| Measure | Time frame |
|---|---|
| Vasoactive drug usage;Postoperative extubation time;ICU Length of Stay;Length of postoperative hospital stay;Incidence of Adverse Events; | — |
Countries
China
Contacts
Public ContactXuesheng Liu
The First Affiliated Hospital of Anhui Medical University
Outcome results
None listed