postoperative nausea and vomiting
Conditions
Interventions
Combination therapy group:The combined therapy group underwent anesthesia induction with intravenous administration of dexmedetomidine at a dosage of 0.5 µg/kg (injected over a period exceeding 10 min
Control group:For the control group, anesthesia induction was achieved via intravenous administration of sufentanil at a dosage of 0.5 µg/kg and propofol at a dosage of 1.5-2.0 mg/kg. During the surgi
Sponsors
Suzhou Ninth Hospital Affiliated to Soochow University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age18~65 years. 2. American Society of Anesthesiologists (ASA) physical status I–III. 3. Body mass index (BMI) 18–30kg/m^2. 4. Scheduled for laparoscopic surgery.
Exclusion criteria
Exclusion criteria: 1. Sick sinus syndrome or severe bradycardia (heart rate (HR) <50 beats/min). 2. History of hypertension or cardiac insufficiency 3. Second-degree or greater atriocentric block without a pacemaker. 4. Left ventricular ejection fraction <40%. 5. Coronary heart disease or history of myocardial infarction. 6. Liver or renal dysfunction (Child-Pugh class C or undergoing renal replacement therapy). 7. Parkinson's disease or Alzheimer's disease. 8. Seizures or epilepsy. 9. Pregnancy or breast feeding. 10. History of chronic pain or preoperative use of sedatives or analgesics. 11. Allergies to medications in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| heart rate;blood pressure;incidence of post-operative nausea and vomiting;nausea;vomiting; | — |
Secondary
| Measure | Time frame |
|---|---|
| anti-emetic treatment;postoperative analgesia rescue; | — |
Countries
China
Contacts
Public ContactChao Zhang
Suzhou Ninth Hospital Affiliated to Soochow University
Outcome results
None listed