Postoperative delirium
Conditions
Interventions
Bupivacaine liposome group:Bilateral transverse abdominal muscle plane nerve block with 266mg (40ml) Bupivacaine liposome injection.
Bupivacaine hydrochloride group:Bilateral transverse abdominis plane nerve block with 40 ml of 0.5% Bupivacaine hydrochloride.
Sponsors
Anesthesiology Department of East Hospital of Qingdao Municipal Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. no gender limitation, aged from 65 to 90 years old, weighting 50-90 kg 2. ASA I-III grade 3. contract COVID-19 within 6 months 4. Preoperative Mini Mental State Scale (MMSE) score = 24 points 5. Surgical time 2-5 hours
Exclusion criteria
Exclusion criteria: 1.A history of severe mental or neurological disorders 2.History of drug or psychotropic substance abuse 3. Long term use of drugs and steroids 4. Preoperative complications of type III or IV hepatic encephalopathy 5. Severe visual and hearing impairment 6. Allergies to bupivacaine and other liposomes 7 Preoperative pulmonary function examination showed moderate or severe ventilation dysfunction.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| anesthesia time;Perioperative blood pressure;Perioperative heart rate; | — |
Countries
China
Contacts
Public ContactXu Lin
Department of Anesthesiology, Qingdao Municipal Hospital
Outcome results
None listed