Patients receiving painless gastroenteroscopy
Conditions
Interventions
Group C (First part):0.08 mg/kg nalbuphine + 0.2-0.3 mg/kg etomidate
Group D (First part):0.1 mg/kg nalbuphine + 0.2-0.3 mg/kg etomidate
Group A (First part):0.04 mg/kg nalbuphine + 0.2-0.3 mg/kg etomidate
Group B (First part):0.06 mg/kg nalbuphine + 0.2-0.3 mg/kg etomidate
Group P (second part):Palonosetron 0.075 mg iv
Group S (second part):0.1 mg scopolamine hydrobromide iv
Group PS (second part):0.075 mg palonosetron +0.1 mg scopolamine hydrobromide iv
Group C (second part):same volume of saline iv
Sponsors
the 900th Hospital of the Joint Logistics Support Force
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 18-65 for painless gastroscopy, regardless of gender; 2. Body mass index (BMI) 18.5-30 kg/m2; 3. American Society of Anesthesiologists (ASA) I~II.
Exclusion criteria
Exclusion criteria: 1. Cannot meet any inclusion criteria; 2. Refusal to accept anesthesia or sedation; 3. Patients with a history of metabolic diseases such as serious abnormalities of heart, brain, lung, liver, kidney and cortex; 4. Those who have received gastrointestinal surgery or other abdominal surgery; 5. Patients with a history of recovery from abnormal surgical anesthesia; 6. ECG suggested: heart rate 180 mmHg and/or diastolic blood pressure > 110 mmHg in patients with hypertension or < 90/60 mmHg in patients with hypotension before examination; 9. With neuromuscular diseases or mental diseases; 10. Hemoglobin lower than 90 g/L; 11. Suspected abuse of narcotic analgesics or sedatives; 12. Predicting the possibility or history of difficult airway; 13. People who are known to be allergic to emulsions and opioids; 14. Subjects are deemed unsuitable for inclusion by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Myoclonic grade;Incidence of nausea and vomiting; | — |
Secondary
| Measure | Time frame |
|---|---|
| Choking cough response;Body dynamic response;Whether additional propofol is needed;behavioral pain scale score for non-intubated, BPS-NI;The length of the examination;The length of time between the end of the examination and the awakening;The length of time from waking up to leaving the operating room;Amount of etomidine;Amount of propofol;blood pressure;Incidence of SpO2 30%;cases of jaw lifting;cases of mask ventilation;Adverse events after awakening;Incidence and intensity of nausea and vomiting;Use of anti-nausea and vomiting drugs;Patient's satisfaction;Duration of dizziness;Duration of drowsiness;Incidence of dry mouth;Incidence of blurred vision;Incidence of headache; | — |
Countries
China
Contacts
Public ContactJianghuai Lin
the 900th Hospital of the Joint Logistics Support Force of the People's Liberation Army
Outcome results
None listed