deliration
Conditions
Interventions
experimental group:Dextramer assisted postoperative analgesia
control group:Traditional analgesic methods
Sponsors
Guangdong Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 79 Years
Inclusion criteria
Inclusion criteria: 1) Age: 65 years old,<80 years old; 2) Undergoing hip and knee replacement surgery under general anesthesia; 3) Use patient controlled intravenous analgesia after surgery; 4) Sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1) Preoperative symptoms include schizophrenia, epilepsy, Parkinson's disease, and myasthenia gravis; 2) Unable to communicate due to coma, severe dementia, or language impairment before surgery; 3) Patients with preoperative sleep apnea [diagnosed with sleep apnea, or STOP-Bang score (Attachment 1) 3 and serum HCO3 28 mmol/L]; 4) Patients with preoperative LVEF<30%, or with sick sinus syndrome, severe sinus bradycardia (heart rate<50 beats/min), atrioventricular block of degree II or above, and no pacemaker implantation; 5) Severe liver dysfunction (Child-Pugh grade C); 6) Severe renal dysfunction (pre operative dialysis); 7) ASA Grade IV or above.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| deliration; | — |
Secondary
| Measure | Time frame |
|---|---|
| analgesic effect;sleep quality;hospital stay;30 day postoperative complication rate;All cause mortality 30 days after surgery;quality of life;Cognitive Function;survival rate; | — |
Countries
China
Contacts
Public ContactMing Zhao
Guangdong Provincial People's Hospital
Outcome results
None listed