Non-male factor infertility
Conditions
Interventions
Control:use of ICSI in PGT-A cycles
Trial:use of conventional IVF in PGT-A cycles
Sponsors
Henan Provincial People's Hospital
Eligibility
Sex/Gender
Female
Age
38 Years to 40 Years
Inclusion criteria
Inclusion criteria: To be eligible to participate in the trial, subjects must meet all of the following criteria: (1) Eligible for IVF, PGT-A cycle patients; (2) At least six oocytes obtain following oocyte retrieval after ovulation induction treatment; (3) Femal age = 40 years, 18kg/m2 = BMI =30kg/m2; (4) The male semen index was normal (semen concentration >5×10^6/mL,number of progressive sperm =5×10^6);
Exclusion criteria
Exclusion criteria: Participants were excluded from the trial if they meet any of the following criteria: (1) IVF or ICSI contraindicated patients: patients with type ? and type ? diabetes mellitus; Patients with undiagnosed liver diseases or functional disorders; Kidney disease or abnormal serum renal function; Anemia; A history of deep vein thrombosis, pulmonary vein thrombosis, or cerebrovascular accident; Uncontrolled hypertension or symptomatic heart disease; Have or suspected history of cervical cancer, endometrial cancer, breast cancer; Unexplained vaginal bleeding; (2) Male factor infertility: severe oligospermia, asthenospermia, teratospermia; (3) Low fertilization rate in previous cycles (fertilization rate <25%); (4) Oocytes and sperm donor patients; (5) Patients using frozen sperm;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The euploid rate;Partenal contamination analysis; | — |
Secondary
| Measure | Time frame |
|---|---|
| Proportion of aneuploid blastocyst;Fertility rate;Rate of embryo degeneration;Proportion of mosaic (mosaic rate of 30%-70%);Proportion of deletion/duplication blastocyst(>4Mb);Grade of D3/D5 blastocysts morphology;Blastocysts formation rate;Number of euploid blastocyst available for transfer; | — |
Countries
China
Contacts
Public ContactZhang Cuilian
Henan Provincial People's Hospital
Outcome results
None listed