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Efficacy evaluation and prognostic improvement of preoperative neoadjuvant radiotherapy combined with surgery in patients with centrally located hepatocellular carcinoma

Efficacy evaluation and prognostic improvement of preoperative neoadjuvant radiotherapy combined with surgery in patients with centrally located hepatocellular carcinoma

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2300072378
Enrollment
Unknown
Registered
2023-06-12
Start date
2023-06-30
Completion date
Unknown
Last updated
2023-06-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

centrally located hepatocellular carcinoma

Interventions

neoRT+LR group:N/A
LR group:N/A

Sponsors

National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Age = 18 years old; 2. Pathological diagnosis of hepatocellular carcinoma after surgical resection; 3. Child-Pugh grade A; 4. ECOG score 0-1 points; 5.Centrally located HCC is defined as a carcinoma adjoined hepatic portals, less than 1 cm from major vascular structures (including the main portal branches, the main trunks of the hepatic veins as well as the inferior vena cava) which are usually located in Couinaud segments I, IV, V, VIII, or at the junction of the central segments.

Exclusion criteria

Exclusion criteria: 1. Have received other forms of radiation therapy; 2. Incomplete clinical data.

Design outcomes

Primary

MeasureTime frame
Disease free survival;Overall Survival;Safety;

Secondary

MeasureTime frame
Pathological remission rate;

Countries

China

Contacts

Public ContactWu Jianxiong

National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

dr_wujx@163.com+86 156 0117 0661

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: May 30, 2026