postoperative pharyngalgia
Conditions
Interventions
Blank control group:Preoperative atomization of 5ml normal saline
Esketamine group:Preoperative atomization inhalation of 0.5mg/kg Esketamine plus normal saline to prepare 5ml
Dexmedetomidine group:Atomized inhalation of 1 ug/kg dexmedetomidine plus physiological saline is 5 ml
Dexmedetomidine combined with esketamine group:Atomized inhalation of 0.25mg/kg esketamine +0.5ug/kg dexmedetomidine plus normal saline was configured as 5ml 30min before surgery
Sponsors
Anesthesiology Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, People’s Republic of China
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: ? ASA level I-II; ? Age = 18 years old; ? BMI<28kg/?? Laparoscopic colorectal cancer resection is planned to be performed on a selective basis; ? Preoperative evaluation predicts that there is no difficulty in intubation; ? Sign informed consent
Exclusion criteria
Exclusion criteria: ? History of sedative, hypnotic and analgesic abuse; ? Patients with uncontrolled hypertension, diabetes, severe stress, liver, kidney and other chronic diseases; ? History of chronic respiratory diseases (such as chronic obstructive pulmonary disease, chronic pharyngitis or asthma), recent history of respiratory infection; ? Preoperative VAS score>2 points; ? Preoperative evaluation predicts patients with intubation difficulties; ? Those who are allergic to general anesthetic ingredients; ? Patients who refused to participate in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative sore throat; | — |
Secondary
| Measure | Time frame |
|---|---|
| heart rate;blood pressure;SpO2;VAS score;epinephrine;Norepinephrine;dopamine; | — |
Countries
China
Contacts
Public ContactJianqing Lin
Anesthesiology Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, People’s Republic of China
Outcome results
None listed