paroxysmal kinesigenic dyskinesia
Conditions
Interventions
Test:perampanel
Control:oxcarbazepine
Sponsors
Shanghai Sixth People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. Conforming to PKD clinical diagnostic criteria: All core symptoms must be present: (1) episodes of involuntary movements, including dystonia, chorea, ballism, or a combination of these, which are precipitated by sudden voluntary movements; (2) no loss of consciousness during attacks; Supporting evidence: (1) aura; (2) duration of attacks = 18 years old, male or female. 3. PKD severity score > 1. 4. Volunteer to participate in clinical trials and be able to understand and obey the research procedures. Informed consent was obtained from the subject.
Exclusion criteria
Exclusion criteria: 1. With allergy to both drugs in this test, or with history of severe allergy; 2. Secondary PKD patients; 3. With other nervous system diseases that affect the evaluation; 4. PKD severity score = 0; 5. With clinically unstable disease history (heart disease, tumor, hemopathy, liver disease, kidney disease, etc.) that may be harmful in the past 1 year; 6. With severe anxiety, depression or agitation; 7. Hepatic or renal dysfunction; 8. Pregnant or lactant women, or subjects who cannot use appropriate contraceptives during the trial; 9. Unable to complete the follow-up; 10. Subjects who participated in another drug test and used other test drug in the last 30 days; 11. Only one of the different subjects from the same family and living in the same residence can be included to avoid treatment confusion; 12. The investigators believe that the subject has poor compliance or there are other factors unsuitable for participating in this clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PKD severity score; | — |
Secondary
| Measure | Time frame |
|---|---|
| adverse event incidence rate; | — |
Countries
China
Contacts
Public ContactLi Cao
Shanghai Sixth People's Hospital
Outcome results
None listed