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Addition of lidocaine to prophylactic ondansetron and dexamethasone in children at high risk for postoperative vomiting. A randomized, controlled, double-blind study

Addition of lidocaine to prophylactic ondansetron and dexamethasone in children at high risk for postoperative vomiting. A randomized, controlled, double-blind study

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300072362
Enrollment
Unknown
Registered
2023-06-12
Start date
2023-06-12
Completion date
Unknown
Last updated
2023-06-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respiratory system complications in patients undergoing tonsillectomy and/or adenoidectomy

Interventions

Group L:The patient was given intravenous injection of lidocaine 1.5 mg/kg for more than 5 minutes and continued pumping of lidocaine 2 mg/(kg·h) until the end of the operation.
Group S:Patients are given intravenous saline of the same volume as lidocaine 1.5 mg/kg for more than 5 minutes and continue to pump the same volume of saline until the end of the operation.

Sponsors

Yichang Central People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
3 Years to 15 Years

Inclusion criteria

Inclusion criteria: Patients between the ages of 3 and 15, with ASA grades I-II, who plan to undergo elective surgery under general anesthesia, with an estimated operation time under anesthesia of =120 minutes, and a VPOP score of 4 or more. The patient himself or the legally authorized person signed the informed consent.

Exclusion criteria

Exclusion criteria: 24-hour preoperative antiemetic therapy, allergy to study medications, postoperative sedation and ventilation, preoperative corticosteroid administration, long QT interval (QT interval: time interval from the beginning of QRS syndrome to the end of T wave) syndrome, and parental rejection.

Design outcomes

Primary

MeasureTime frame
The number of times of retching or vomiting in 24 hours after operation;VAS score within 24 hours after surgery;CHIPPS score within 24 hours after surgery;

Secondary

MeasureTime frame
Number of people need additional analgesics;Sedation score;extubation time;extubation cough degree;

Countries

China

Contacts

Public ContactGong Yuan

Yichang Central People's Hospital

gy-yc@163.com+86 139 8674 6821

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026