Hepatic surgery for cancer
Conditions
Interventions
rhBNP group:Recombinant human brain natriuretic peptide (0.5 mg) is diluted in 50 mL of normal saline. Infusion of a 1.5 µg/kg loading dose of rhBNP solution followed by a continuous infusion of 0.007
non-rhBNP group:Fifty milliliter of normal saline is infused using the same protocol.
Sponsors
The First Affiliated Hospital with Nanjing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 79 Years
Inclusion criteria
Inclusion criteria: Patients with hepatic cancer, aged 18–79 years, with American Society of Anesthesiologists grades I–III, scheduled for elective laparoscopic hepatectomy.
Exclusion criteria
Exclusion criteria: Child-Pugh grade C, renal insufficiency [estimated glomerular filtration rate = 60 mL/min/1.73 m2, creatinine level > 1.1 mg/dL (female)/ > 1.3 mg/dL (male), or renal failure necessitating hemodialysis], severe heart disease (unstable angina, chronic heart failure, and functional New York Heart Association class III or above), poor control of hypertension and diabetes, coagulation disorders, history of upper abdominal surgery, open conversion prior to surgery, palliative surgery, intraoperative critical events, and patients who did not undergo the Pringle maneuver.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intraoperative blood loss; | — |
Secondary
| Measure | Time frame |
|---|---|
| Central venous pressure;Drop ratio of central venous pressure;Surgical field bleeding grade;Airway pressure;Pneumoperitoneum pressure;Intraoperative hemodynamic data;Demographic data;Perioperative blood tests data;Perioperative arterial blood gas analysis data;Surgery and anesthesia-related data;Intraoperative input/output;postoperative complications; | — |
Countries
China
Contacts
Public ContactBo Gui
The First Affiliated Hospital with Nanjing Medical University (Jiangsu Province Hospital)
Outcome results
None listed