Postoperative delirium
Conditions
Interventions
Sponsors
Xi'an International Medical Center Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 90 Years
Inclusion criteria
Inclusion criteria: Geriatrc patients undergoing orthopedic surgery under general anesthesia, 90>age>65, 30>BMI>18, no gender limitation, ASA I-III, surgery duration time>1 hour.
Exclusion criteria
Exclusion criteria: 1) Patients with endocrine diseases such as Cushing syndrome, pituitary adenomas and adrenal tumors; 2) Patients who use hormone drugs within three months before operation; 3) Patients with asthma; 4) Patients with severe respiratory diseases (obstructive sleep apnea syndrome, acute respiratory infection, acute attack of chronic obstructive pulmonary disease, uncontrolled asthma, active massive hemoptysis, severe pulmonary hypertension, etc.). 5) Acute heart failure; unstable angina pectoris; myocardial infarction within 6 months before screening; resting ECG heart rate ULN+3s and / or APTT > ULN+10s); 10) Abnormal liver function: AST and / or ALT = 2.5 × ULN,TBIL = 1.5 × ULN. 11) Abnormal renal function: urea or urea nitrogen = 1.5 × ULN, serum creatinine was higher than the normal limit; 12) History of drug abuse, drug use and alcohol abuse in the 2 years before the beginning of the screening period. Alcoholism means drinking an average of more than 2 units of alcohol per day (1 unit = 360mL beer or 45mL liquor or 150mL wine with 40% alcohol content). 13) Patients who did not receive regular antihypertensive therapy or poorly controlled blood pressure (sitting systolic blood pressure = 160mmHg or = 90mmHg during screening, and / or diastolic blood pressure = 100 mmHg during screening); 14) Patients whose blood sugar was not satisfactorily controlled (random blood glucose = 11.1mmol/L during screening); 15) Patients who are allergic or contraindicated to benzodiazepines, opioids, sevoflurane and their drug components; 16) Patients who are determined to have difficulties in respiratory tract management (modified M score IV); 17) Patients have participated in any clinical drug trials as subjects in the past 3 months and have used the trial drugs; 18) The expected operation time is less than 1 hour; 19) other factors that may interfere with the results of the experiment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative delirium ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative cognitive dysfunction ;Awakening time;PACU residence time;Ramsay Sedation Score when leaving PACU;NRS score when leaving PACU;Length of stay in hospital;Mortality rate;Adverse reactions during anesthesia and recovery period; | — |
Countries
China
Contacts
Public ContactJiaxuan He
Xi'an International Medical Center Hospital
Outcome results
None listed