Parkinson‘disease
Conditions
Interventions
Parkinson's disease patient:none
health control:none
Sponsors
Department of Neurology, Fujian Institute of Geriatrics, Fujian Medical University Union Hospital
Eligibility
Sex/Gender
All
Age
40 Years to 75 Years
Inclusion criteria
Inclusion criteria: PD enrollment criteria 1. Must give informed consent to the trial and voluntarily sign a written informed consent form, be able to maintain good communication with the investigator and comply with the various requirements of the clinical trial; 2. Subjects must be 40-75 years of age (including borderline values) at the time of screening, with no restriction on gender. 3. Meet the International Parkinson and Movement Disorders Society (MDS) diagnostic criteria for primary Parkinson's disease, which are based on a primary symptom of one by one motor slowing, plus at least one of the following symptoms: resting tremor, myotonia, and the absence of any other known or suspected cause of Parkinson's syndrome; 4. Hoehn-Yahr scale = 25; Enrollment criteria for healthy subjects 1. Healthy non-PD population; 2.Subjects aged 40-75 years (including borderline values) at the time of screening, regardless of gender. 3.Must give informed consent to the trial, voluntarily sign a written informed consent form, be able to maintain good communication with the investigator and comply with the requirements of the clinical trial.
Exclusion criteria
Exclusion criteria: Subjects meeting any of the following criteria shall not be enrolled in this study: 1. various secondary Parkinsonian syndromes (including traumatic, pharmacogenetic, neoplastic, vascular, toxic, hydrocephalus, etc.) and Parkinsonian superimposed syndrome; 2. other diseases that cause gait disorders, including injuries to the joint parts of the spine, muscle spasms, strokes, peripheral neuropathies, muscle diseases, hydrocephalus and cognitive disorders; 3. significant cognitive impairment (MMSE score) illiteracy = 17; elementary school (= 6 years of education) = 20; secondary school or above (> 6 years of education) = 24; 4. with vital organ (heart, lung, liver, kidney, etc.) failure, malignant tumor, unstable condition and other serious medical diseases 5. those with serious behavioral problems or mental disorders. 6. Anyone else who, in the opinion of the investigator, needs to be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mini-mental State Examination;Montreal Cognitive Assessment;The 39-Item Parkinson's Disease Questionnaire;Hamilton Depression Rating Scale;hoehn-yahr stage;Movement Disorder Society-Sponsored Revision Of The Unified Parkinson's Disease Rating Scale;Wearable devices measure gait parameters; | — |
Countries
China
Contacts
Public ContactQinyong Ye
Department of Neurology, Fujian Institute of Geriatrics, Fujian Medical University Union Hospital
Outcome results
None listed