Lung cancer
Conditions
Interventions
Gold Standard:Histopathological findings combined with imaging findings
Index test:Exosome related nucleic acid, metabolites and protein detection data.
Sponsors
Zhongshan Hospital Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Experimental group (lung cancer group, 1623 cases) (1) At least 18 years old; (2) Gender is not limited; (3) Smoking history is not limited; (4) It was confirmed by histopathology as lung cancer; 2. Control group (384 cases) (1) Healthy people, age, sex, smoking history matched with the experimental group, no lung disease; (2) Patients with benign pulmonary nodules; (3) Patients with other lung diseases, including but not limited to emphysema, chronic obstructive pulmonary disease, tuberculosis, bronchiectasis, pulmonary infection, interstitial lung disease, pneumothorax, pleural effusion, pulmonary embolism, asthma, allergic alveolitis, Wegener granuloma, etc.
Exclusion criteria
Exclusion criteria: 1. Experimental group (lung cancer group) (1) No histopathologic diagnosis (including pleural effusion only pleural hydrocytological diagnosis) (2) Patients who cannot obtain the necessary laboratory examination and imaging examination results; (3) Patients who could not provide complete information on lung cancer risk factors and related medical history; (4) There is a history of any malignancies other than basal cell carcinoma. 2. Control group (1) No diagnostic information related to benign lung diseases can be provided (only applicable to patients with nodules and benign lung diseases); (2) There is a history of any cancer other than basal cell carcinoma.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Exosomal nucleic acid, metabolites and protein;Sensitivity;Specifity;Area under the receiver operating characteristic curve; | — |
Countries
China
Contacts
Public ContactJian Zhou
Zhongshan Hospital, Fudan University
Outcome results
None listed