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Effect of Esketamine combined with remifentanil on EC50 required to suppress coughing reaction during extubation in patients undergoing anterior cervical decompression

Effect of Esketamine combined with remifentanil on EC50 required to suppress coughing reaction during extubation in patients undergoing anterior cervical decompression

Status
Active, not recruiting
Phases
Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300072315
Enrollment
Unknown
Registered
2023-06-09
Start date
2023-06-10
Completion date
Unknown
Last updated
2023-06-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anterior cervical canal decompression

Interventions

Control group:Equal volume normal saline was injected intravenously

Sponsors

The First Affiliated Hospital of Fujian Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: (1) ASA grade ? or ?; (2) Age 18-65 years old; (3) Informed consent signed by the patient and his family; (4) Patients undergoing elective tracheal intubation with anterior cervical decompression under general anesthesia; (5) Body Mass Index (BMI) was 18-30kg /m2.

Exclusion criteria

Exclusion criteria: (1) History of allergy to the anesthetic drugs in the study; (2) Patients who refuse to cooperate or have related mental illness; (3) patients with severe obstructive ventilation dysfunction, bronchial asthma, upper respiratory infection; (4) Patients with severe cardiovascular disease and obvious abnormal liver and kidney function; (5) Patients at risk of significantly increased intracranial pressure or intraocular pressure; (6) Patients with a history of sedative and analgesic drug abuse.

Design outcomes

Primary

MeasureTime frame
Coughing during extubation;

Secondary

MeasureTime frame
HR;MAP;SPO2;PETCO2;RR;

Countries

China

Contacts

Public ContactLanying Lin

The First Affiliated Hospital of Fujian Medical University

linlanying@163.com+86 138 5908 9869

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026