Oral and intestinal microbiome alterations after taking gastric acid inhibitors
Conditions
Interventions
Control:Take probiotics approximately 1 hour after breakfast for seven consecutive days.
PPI:Take PPI approximately 0.5 hour before breakfast for seven consecutive days, then continue taking PPI approximately 0.5 hour before breakfast for another seven consecutive days while taking probio
H2RA:Take H2RA approximately 0.5 hour after breakfast for seven consecutive days, then continue taking H2RA approximately 0.5 hour after breakfast for another seven consecutive days while taking probi
Sponsors
Huazhong University of Science and Technology, College of Life Science and Technology
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. aged 18 - 45 years 2. 19 kg/m2=BMI=24 kg/m2 3. no smoking and no history of alcohol abuse 4. good physical health, without severe diseases such as cancer, cardiovascular diseases, or impaired liver and kidney function 5. no severe oral diseases, no gastrointestinal diseases 6. no use of antibiotics, probiotics, or gastric acid inhibitors within the previous three months
Exclusion criteria
Exclusion criteria: 1. Long-term smoking or have a history of drug or alcohol abuse 2. Use of antibiotics, probiotics, or gastric acid inhibitors within the previous three months 3. Having cancer, cardiovascular diseases, and other related conditions 4. Having long-term chronic oral or gastrointestinal diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Oral microbiota;Gut microbiota; | — |
Secondary
| Measure | Time frame |
|---|---|
| Body mass index;Health condition;Dietary intake; | — |
Countries
China
Contacts
Public ContactWei-Hua Chen
Huazhong University of Science and Technology, College of Life Science and Technology
Outcome results
None listed