Children with autism undergoing magnetic resonance imaging examination
Conditions
Interventions
Research group:Before the magnetic resonance examination, intramuscular injection was administered with 3ug/kg of dexmedetomidine, 0.2mg/kg of midazolam, and 0.02mg/kg of atropine.
Sponsors
Qilu Hospital of Shandong University
Eligibility
Sex/Gender
All
Age
2 Years to 14 Years
Inclusion criteria
Inclusion criteria: 1) Meet the diagnostic criteria of autism spectrum disorder in DSM-5; 2) Age 2-14 years old, regardless of gender; 3) Proposed MRI examination; 4) ASA score level I-II; 5) Clearly understand, voluntarily participate in the study, and have their legal guardian sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1) Individuals with contraindications to general anesthesia; 2) Patients who have used sedatives and analgesics within 24 hours or anesthetics within 5 days, and those who have taken benzodiazepines or opioid analgesics within the past 6 months; 3) Suffering from brain organic disease, trauma and other serious nervous system disease; 4) Children with fragile X syndrome and Rett syndrome; 5) Allergies or contraindications to chloral hydrate, benzodiazepines, dexmedetomidine, atropine, flumazenib, and their drug components; 6) Patients diagnosed with difficulty in respiratory management 7) Appearing symptoms of upper respiratory tract colds; 8) Children who do not fast or drink according to the doctor's instructions; 9) Participated in drug clinical trials as a subject within the past 3 months; 10) Researchers believe that patients should not participate in this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Success rate of sedation with the first dose of anesthesia; | — |
Secondary
| Measure | Time frame |
|---|---|
| Perianesthesia hemodynamic indicators;Sedation onset time;Calm Awakening Time;After the first dose of medication fails to calm down, the dosage and usage of additional medication should be supplemented; | — |
Countries
China
Contacts
Public ContactTao Meng
Qilu Hospital of Shandong University
Outcome results
None listed