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Oral metformin treatment for unilateral upper limb lymphedema after breast cancer multicenter prospective randomized controlled study

Oral metformin treatment for unilateral upper limb lymphedema after breast cancer multicenter prospective randomized controlled study

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300072264
Enrollment
Unknown
Registered
2023-06-08
Start date
2024-04-01
Completion date
Unknown
Last updated
2024-09-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

lymphedema

Interventions

Experimental group:Pressure treatment with metformin and a pressure bandage
Control group:Pressure treatment with a placebo and a pressure bandage

Sponsors

Affiliated Hospital of Zunyi Medical University
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
30 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. The clinical diagnosis of breast cancer in women after unilateral upper limb lymphedema international society classification for patients with stage I-II lymphedema: Mild (I level): edema, body pressure can appear sag, raise the body of most edema disappeared, no fibrosis sample skin damage; Moderate (II level) : when the pressure, edema, body is not a depressed, limb edema disappears when raised, with moderate fibrosis; 2. Aged 30-70 years.

Exclusion criteria

Exclusion criteria: 1. Patients with metformin contraindicated; 2. Patients with a history of metformin to take 3 months; 3.Patients with clinically diagnosed diabetes 4. Lactation, for patients with pregnancy; 5. Serious heart, lung, liver, kidney disease, as well as the history of tumor patients; 6. She history is less than 3 months; 7. In patients with mental illness; 8. Immunodeficiency patients.

Design outcomes

Primary

MeasureTime frame
Limb circumference;

Secondary

MeasureTime frame
The quality of life;Skin thickness under color Doppler ultrasound;weight;Blood Sugar;

Countries

China

Contacts

Public ContactDeng Chengliang

Affiliated hospital of Zunyi Medical University

cheliadeng@sina.com+86 150 8511 5296

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026