Pneumonia
Conditions
Interventions
Case series:N/A
Sponsors
Union Jiangbei Hospital,Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) Patients aged 18-80 years with severe pulmonary infection and pneumonia related clinical manifestations: recent cough, sputum, or exacerbation of pre-existing respiratory symptoms, with or without purulent sputum, chest pain, dyspnea, and hemoptysis ,Fever ,Signs of lung consolidation and/or pulmonary auscultation of moist rales ,Peripheral blood leukocytes >10*109 / L or <4 *109 / L, with or without nuclear shift to the left. 2) The diagnosis of severe pneumonia was based on IDSA/ATS. 3) Patients who agree to undergo mNGS testing.
Exclusion criteria
Exclusion criteria: 1) non-infectious pneumonia 2) Severe immunosuppression 3) Active tuberculosis or end-stage disease 4) There is a "DNR" signature 5) Patients with a history of antibiotic or other drug allergies 6) Pregnant women 7) Study other patients whom the doctor deems unsuitable for the study 8) Do not agree with mNGS detection
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Positive rate of detection;Day 28 mortality; | — |
Secondary
| Measure | Time frame |
|---|---|
| Total hospitalization expenses;MODS incidence rate;Incidence of septic shock;Total hospitalization time (days);ICU hospitalization time (days);Mechanical ventilation time (h);Use of vasoactive drugs; | — |
Countries
China
Contacts
Public ContactJun Guo
Union Jiangbei Hospital,Huazhong University of Science and Technology
Outcome results
None listed