Hyperuricemia
Conditions
Interventions
Lactobacillus rhamnosus CCFM1130:Lactobacillus rhamnosus CCFM1130
Lactobacillus reuteri CCFM1132:Lactobacillus reuteri CCFM1132
Lactobacillus gasseri CCFM1133 :Lactobacillus gasseri CCFM1133
placebo:placebo
Sponsors
Yixing People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) He/She meets the diagnostic criteria of hyperuricemia; (2) 18 years = age = 65 years, male or female; (3) The blood uric acid level was detected twice on an empty stomach on different days, which was higher than 420 in men µ Mol/L, higher than 360 for women µ mol/L (4) Good compliance, able to comply with the requirements of clinical trials; (5) The subject or guardian has signed the informed consent form; (6) The patients filled in the written informed consent form, the International Physical Activity Scale and the dietary structure questionnaire, and promised to cooperate with the study during the whole trial period.
Exclusion criteria
Exclusion criteria: (1) Equivalent intake of ethanol>40 g/week; (2) Take non-steroidal anti-inflammatory drugs, antibiotics and corticosteroids, anti-tumor drugs, anti-tuberculosis drugs and some Chinese herbal and mineral drugs (Acer truncatum/arsenic trioxide) regularly in the past six months; (3) Abuse of narcotics, psychotropic substances and cigarettes in the past 6 months; (4) Ingestion in the past 6 months caused gastric acid deficiency, amiodarone, sodium valproate, prednisone, tamoxifen, piperacillin and methotrexate, liver fat induction drugs, hormone drugs, statins, antihypertensive drugs and ursodeoxycholic acid anti-secretory drugs. (5) During the study period or in the past 3 months, supplement nutrients at least twice a week, such as probiotics, vitamins/minerals, antioxidants and ?- 3 (6) Patients with acute gout attack (7) Secondary hyperuricemia caused by glomerular disease, lead poisoning, hematological disease, tumor radiotherapy, chemotherapy or long-term use of diuretics. Patients with serious primary diseases and mental diseases such as cardiovascular, cerebrovascular, liver and kidney and hematopoietic system. (8) Patients with long-term or recent use of drugs that affect blood uric acid. (9) In the past 6 months, the body weight has been rapidly reduced, and total parenteral nutrition and protein malnutrition have occurred. (10) Pregnant or lactating women (11) Allergic or intolerant to the ingredients of the probiotic products tested; (12) The patient's compliance is poor and the possibility of follow-up is poor;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fecal flora;Renal routine;Fecal flora genomics;Blood routine;hepatic function;Fecal routine; | — |
Secondary
| Measure | Time frame |
|---|---|
| Height;Weight; | — |
Countries
China
Contacts
Public ContactLiyun Wang
Yixing People's Hospital
Outcome results
None listed