Acute gastrointestinal injury of sepsis
Conditions
Interventions
Intervention group:Intervention group+low molecular weight heparin sodium,4000U,qd, subcutaneous injection
Control group:Conventional treatment
Sponsors
The First Hospital of Lanzhou University
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: a. Age =18 years old, gender unlimited; b. Patient meets the diagnostic criteria for sepsis 3.0 (positive or suspected infection with SOFA=2 points) ; c. Patient meets the AGI diagnostic criteria [(ESICM) 2012 Recommendation AGI severity rating ; d. Informed consent signed by the patient or his or her family.
Exclusion criteria
Exclusion criteria: a. Combined with underlying gastrointestinal diseases (tumor, tuberculosis, inflammatory diseases, etc.); b. Gastrointestinal surgery; c. Patients with terminal disease who are expected to die within 24 hours; d. Patients with neurogenic shock, cerebrovascular accident, or craniocerebral trauma; e. Patients clear infection foci affect the reliability of the study; f. Patients with definite hemorrhagic disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| heparanase;syndecan-1;LC3B;intestinal fatty acid binding protein;D-lactate;CD4/CD8;IL-6;TNF-a;AGI grade; | — |
Secondary
| Measure | Time frame |
|---|---|
| motilin;gastrin;APTT;D-dimer;antiXa factor;SOFA score;APACHE IIscore; | — |
Countries
China
Contacts
Public ContactLi-Ping Liu
the First Hospital of Lanzhou University
Outcome results
None listed