Sepsis
Conditions
Interventions
Nano-selenium in combination with Xuebijing injectionon:On the basis of Xuebijing treatment, 4 nano-selenium capsules (100ug selenium/capsule) were fed with nasogastric tube once a day for 7 days or u
Xuebijing injectionon:100ml Xubijing injection plus 0.9% sodium chloride injection 100ml was given intravenously for 7 days or until the patient was discharged from ICU or died.
Sponsors
The First Affiliated Hospital of Jinan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) Patients aged 18 to 80 years, both males and females; 2) Patients with Sepsis defined as Sepsis 3.0 admitted to ICU; 3) Patients expected to stay in ICU for more than 48 hours; 4) Patients receiving enteral nutrition.
Exclusion criteria
Exclusion criteria: 1) Pregnant women; 2) Patients known to be allergic to Xuebijing and selenium supplements; 3) Patients with malignant tumor receiving radiotherapy and chemotherapy; 4) Patients with chronic renal insufficiency requiring dialysis (GFR < 60 ml/min/1.73m2); 5) Chronic severe liver insufficiency (Child-Pugh grade C); 6) Patients receiving blood purification treatment; 7) Patients on immunosuppressive drugs or those who have received an organ transplant within the last six months; 8) Intolerance to enteral nutrition, intestinal ischemia-necrosis obstruction, pancreatitis, short bowel syndrome, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Inflammatory biomarkers, including TNF-a?IL-1ß?IL-6?IL-10;Immune function, including Th1/Th2?CD4+ T?CD8+ T?mHLA-DR;Oxidative stress indices, including GPX-3?SOD?MDA; | — |
Secondary
| Measure | Time frame |
|---|---|
| Selenium levels and selenoprotein;Clinical outcomes, including ICU mortality, in-hospital mortality, length of ICU stay, length of hospital stay, SOFA score; | — |
Countries
China
Contacts
Public ContactHai-Yan Yin
The First Affiliated Hospital of Jinan University
Outcome results
None listed