thyroid cancer
Conditions
Interventions
Clinical trial group:On the basis of the control group, 300,000 U of vitamin D was taken orally 2 to 7 days before surgery (one cholvidine milk).
Control group:At 6:00 a.m. on the first day after surgery, blood was drawn to measure blood calcium and then intravenous calcium supplement 3g/d×2d. Calcium and Vitamin D tablets (Calcic tablets with
Sponsors
Shanghai Sixth People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1) 18= age =65 years old, gender is not limited 2) 40= body weight =80KG 3) Patients with thyroid cancer who planned to undergo total thyroidectomy (open or endoscopic surgery in the same operation group, with at least one central lymph node dissection, except bilateral lymph node dissection) 4) Baseline serum 25(OH)D=60ng/mL
Exclusion criteria
Exclusion criteria: 1) Hepatorenal insufficiency (defined as any of the following conditions: positive jaundice index, ALT > 75U/L, AST > 69 U/L, Cr > 92µmol/L, BUN > 7.1mmol/L) 2) Hypervitamin D, hyperphosphatemia with renal rickets (> 1.6mmol/L), hypocalcemia ( 2.75mmol/L), hypomagnesia (< 0.7mmol/L) before surgery 3) ASA grading =3 4) Daily vitamin D (=200IU/d) or calcium supplement (=600mg/d) 5) Have a medical condition that affects the absorption of vitamin D or calcium, such as celiac disease, small intestine dysfunction, etc 6) Preoperative use of drugs that affect calcium or vitamin D absorption, including antiepileptics, bisphosphonates, cisplatin, aminoglycosides, glucocorticoids, diuretics or proton pump inhibitors
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| serum calcium; | — |
Countries
China
Contacts
Public ContactZheng Ding
Shanghai Sixth People's Hospital
Outcome results
None listed