Analgesia in patients with mechanical ventilation in ICU
Conditions
Interventions
Nabulphine combined with hydromorphone group:Nabulphine with hydromorphone for analgesia
Hydromorphone group:hydromorphone for analgesia
Sponsors
Union Jiangbei Hospital,Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) Age =18 years and =80 years; 2) Patients with mechanical ventilation who are expected to stay in ICU for more than 48 hours; 3) Moderate to severe pain requiring analgesic drugs; 4) Obtain informed consent from patients or family members.
Exclusion criteria
Exclusion criteria: 1) Under 18 years of age, or over 80 years of age; 2) pregnancy or lactation; 3) Patients undergoing surgery under general anesthesia within 48 hours; 4) Severe, pre-existing substantial liver disease with clinically significant portal hypertension, Child-Pugh grade C cirrhosis, or acute liver failure; 5) Patients with hemodynamic instability, systolic blood pressure (SBP) 15µg/kg/min, norepinephrine >15ug/min) are required; 6) Long-term use of narcotic analgesics, hypnotics and psychotropic drugs 7) Patients with severe craniocerebral injury, brain tumor, and increased intracranial pressure are prone to respiratory depression; 8) Patients with a history of alcohol or drug abuse; 9) Any conditions that interfere with the correct assessment of cognitive function, such as speech and sensory disorders or psychiatric disorders (dyspnea or organic mental dysfunction); 10) Failure to obtain informed consent or authorization; 11) Participate in other exploratory clinical trials within 6 months prior to screening; 12) Allergic reaction to the experimental drug.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The percentage of time that reached the target analgesic score range at all time points during drug administration was studied; | — |
Secondary
| Measure | Time frame |
|---|---|
| RASS score at each time point;Vital signs (MAP, SBP, HR, RR, SPO2);Occurrence and treatment of adverse events;Delirium incidence;Dosage of analgesic and sedative drugs in two groups;Mechanical ventilation time;Length of stay in ICU; | — |
Countries
China
Contacts
Public ContactJun Guo
Union Jiangbei Hospital,Huazhong University of Science and Technology
Outcome results
None listed