Effect of mecobalamin and compound betamethasone for paravertebral nerve block on postoperative chronic pain in patients undergoing thoracoscopic surgery

Effect of mecobalamin and compound betamethasone for paravertebral nerve block on postoperative chronic pain in patients undergoing thoracoscopic surgery: a single-center, prospective, randomized controlled clinical study

Status

Recruiting

Phases

Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300072194

Enrollment

Unknown

Registered

2023-06-06

Start date

2022-12-05

Completion date

Unknown

Last updated

2023-06-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Video assisted thoracic surgery

Interventions

Experimental group 1 (Group E):Paravertebral block was performed with mecobalamin and compound betamethasone combined with ropivacaine

Experimental group 2 (group M):Paravertebral block was performed with mecobalamine combined with ropivacaine

Experimental group 3 (group B):Paravertebral block was performed with compound betamethasone combined with ropivacaine

Control group (group C):Paravertebral block was performed with ropivacaine

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1.Age 18-75 years old; 2.Patients undergoing elective thoracoscopic surgery; 3.ASA grade I-III.

Exclusion criteria

Exclusion criteria: 1. Contraindications to paravertebral nerve block; 2. Allergy or contraindication to study drugs; 3. History of thoracic surgery; 4. Chronic chest and back pain; 5. Long-term use of analgesics; 6. Suffering from severe cardiovascular and cerebrovascular diseases or liver and kidney failure; 7. Preoperative diagnosis of diabetes mellitus; 8. Preoperative diagnosis of depression; 9. Inability to cooperate with research (e.g. communication difficulties, mental illness, etc.); 10. Refusal to participate in the study.

Design outcomes

Primary

Measure	Time frame
Incidence of postoperative chronic pain at 3 months after surgery;	—

Secondary

Measure	Time frame
Incidence of postoperative chronic pain at 6 months after surgery;NRS scores at rest;NRS scores for motor status;DN4 score;	—

Countries

China

Contacts

Public ContactHeng lei

348654564@qq.com13914888690

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026