Nutcracker esophagus
Conditions
Interventions
Diltiazem combined Lansoprozle—Placebo group:Diltiazem 30mg Qid combined Lansoprozle 30mg Qd
Placebo treatment
Placebo—Diltiazem combined Lansoprozle group:Placebo treatment
Diltiazem 30mg Qid combined Lansoprozle 30mg Qd
Sponsors
Suining Central Hospital
Eligibility
Sex/Gender
All
Age
15 Years to 75 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria were as follows: 1) age between 15-75 years, good functions of cardiopulmonary, liver and kidney, without severe diseases; 2) diagnosed to be NE. Diagnosis of NE was based on Gothenburg and defined as any of the swallows with a contractile pressure greater than 180 mm Hg(1mmHg=0.133kPa).
Exclusion criteria
Exclusion criteria: Exclusion criteria were as follows: 1) 24-hour pH monitoring did not indicate pathological acid reflux; 2) with coronary artery disease, severe arrthymia or other severe heart diseases; 3) cannot endure invasive examinations, such as EGD, esophageal manometry and 24h pH monitoring; 4) chronic alcoholism (male with 40g/day, female with 20g/day); 5) known other primary esophageal motility diseases, such as achalasia, ect. 6) known esophageal or gastric malignant diseases; 7) with gastric or duodenum active ulcer; 8) history of endoscopic or surgical treatment of esophagus or gastric; 9) pregnancy or nursing at the time of treatment;10) refuse to participate the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Esophageal contractile pressure;Esophageal acid exposure; | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical symptoms; | — |
Countries
China
Contacts
Public Contactsuyu He
Suining Central Hospital
Outcome results
None listed