Prediabetes
Conditions
Interventions
Prediabetes control group:Continuation of the existing treatment regimen (excluding metformin or replacement with other antidiabetic medications) or non-pharmacological intervention without medication
Metformin group:Regular oral administration of metformin 500mg three times daily for a duration of 3 months, with exclusion from the aerobic exercise program due to inability to meet the aforementione
Aerobic exercise group:Continuation of the existing treatment regimen (excluding metformin or substitution with other antidiabetic medications for metformin) or non-pharmacological intervention withou
Combination therapy group:Regular oral administration of metformin 500mg three times daily, in conjunction with aerobic exercise, for a duration of 3 months.
Sponsors
Shengjing Hospital of China Medical University
Eligibility
Sex/Gender
All
Age
25 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1) Clinical diagnosis of type 2 prediabetes: fasting glucose range of 6.1-6.9 mmol/L and/or 2-hour postprandial glucose value of 7.8-11.0 mmol/L; 2) High risk group as determined by two endocrinologists with more than 5 years of practice according to the guidelines; 3) No contraindications to MRI scanning; 4) Age located between 25 and 70 years
Exclusion criteria
Exclusion criteria: 1) Have clinically confirmed type 1/type 2 diabetes or a combination of all acute complications associated with diabetes; 2) Suffering from acute liver and kidney diseases; 3) suffering from acute infection, fever, trauma and other endocrine diseases that may affect the blood glucose value of the organism (such as hyperthyroidism, etc.) 4) suffering from acute cerebrovascular disease, coronary artery disease, chronic cardiac insufficiency and hyperuricemia, celiac disease, etc; 5) Those who have exercised strenuously within the last 1 week; 6) those who need to be bedridden for a long time for various reasons 7) patients with metallic foreign bodies in their bodies, poor self-control and unable to cooperate with the examination;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Muscle-T2;Muscle-ADC;Muscle-FA;Muscle-IMCL;Skeletal muscle intermuscular fat content;Body Mass Index; | — |
Secondary
| Measure | Time frame |
|---|---|
| Visceral fat content;Fasting blood glucose;Fasting blood insulin;Glycated hemoglobin; 2-h postprandial glucose;2-h insulin;Waist Circumference;Abdominal circumference; | — |
Countries
China
Contacts
Public ContactShinong Pan
Shengjing Hospital of China Medical University
Outcome results
None listed