depression
Conditions
Sponsors
The Affiliated Hospital of Hangzhou Normal University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Meet the DSM-V diagnostic criteria for depression, diagnosed as MDD patients; (2) HAMD>=18 (Melzer et al., 2012) or MADRS > = 20 (Müller et al., 2003); MDQ < 7. (3) Use the Brief International Neurological Psychiatry Interview 7.0.0 (M.I.N.I.7.0.0) to confirm that the subject is currently a MDD patient. (4) No gender restriction, aged 18 to 65 years; (5) Subjects who can understand and are willing to strictly abide by the clinical trial protocol to complete the trial and sign the informed consent.
Exclusion criteria
Exclusion criteria: (1) Those with contraindications to magnetic resonance and TMS; (2) Serious physical and nervous system diseases; (3) Schizophrenia, bipolar disorder, history of abuse of tobacco, alcohol and other psychoactive substances; (4) The patient is a pregnant or lactating woman or planning to become pregnant; (5) Immunomodulators and hormone preparations for at least half a year, antipyretic and analgesic drugs for 2 weeks; (6) Those considered unsuitable for inclusion by researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depression Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hamilton Anxiety Scale;Montgomery-Asberg Depression Rating Scale;Mood Disorder Questionnaire;Snaith-Hamilton Pleasure Scale;The Insomnia Severity index;Self-rating anxiety scale;Self-rating depression scale;Beck Scale for Suicide Ideation-Chinese Version;Visual Analogue Score;Digit-symbol substitution test;digital span test;Functional connectivity;Amplitude of Low Frequency Fluctuation;regional homogeneity; | — |
Countries
China
Contacts
Public ContactZang Yufeng
The Affiliated Hospital of Hangzhou Normal University
Outcome results
None listed