monophasic and biphasic depression
Conditions
Interventions
Group1:Functional connection location and classical coordinate location of anterior knee cingulate gyrus were randomly assigned.
Sponsors
The Affiliated Hospital of Hangzhou Normal University
Eligibility
Sex/Gender
All
Age
20 Years to 55 Years
Inclusion criteria
Inclusion criteria: (1) Hamilton rating scale for depression (HAMD) 17-item score > 17. (2) The Brief International Neuropsychiatric Interview 7.0.0 (M.I.N.I.7.0.0) was used to confirm that the subjects were currently depressed. (3) All genders, age 16-65 years. (4) Subjects who can understand and are willing to strictly comply with the clinical trial protocol to complete this trial and sign the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Contraindications to MRI and TMS.(2) Severe physical and neurological disorders. (3) Schizophrenia, history of tobacco, alcohol and other psychoactive substance abuse. (4) The patient is a pregnant or lactating female or planning to become pregnant. (5) Taking immunomodulators and hormonal agents for at least 6 months and antipyretic drugs for 2 weeks. (6) Those who are considered by the investigator to be inappropriate for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depression Scale, HAMD;Hamilton Anxiety Scale, HAMA;Theamplitudeof low-frequency fluctuations, ALFF;Functional connection, FC;reagional homogeneity, ReHo; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mood Disorder Questionnaire, MDQ;Snaith-Hamilton Pleasure Scale, SHAPS;The Insomnia Severity index, ISI;six item the Hamilton Depression Scale, HAMD-6;Beck Scale for Suicide Ideation-Chinese Version, BSI- CV;Visual Analogue Score, VAS; | — |
Countries
China
Contacts
Public ContactZang Yufeng
Hangzhou Normal University
Outcome results
None listed