depression
Conditions
Interventions
Group 2:pgACC FC-guided iTBS
Sponsors
The Affiliated Hospital of Hangzhou Normal University
Eligibility
Sex/Gender
All
Age
12 Years to 18 Years
Inclusion criteria
Inclusion criteria: (1) HAMD-17 > 17; (2) Meet the diagnostic criteria for depression in the International Classification of Diseases, DSM-V, diagnosed as MDD patients or bipolar depressive episode stage; (3) The current depressive episode was confirmed by the questionnaire of Emotional Disorders and schizophrenia in school-age children, KidDI-SADS Lifetime Edition (K-SADS-PL); (4) No gender limitation, age 12-18 years; (5) Subjects who are able to understand and willing to strictly follow the clinical trial protocol to complete the study, have informed consent from the guardian and can sign informed consent.
Exclusion criteria
Exclusion criteria: (1) Contraindicated patients with MRI and TMS; (2) Serious physical and nerve system diseases; (3) Schizophrenia, history of abuse of tobacco, alcohol and other psychoactive substances; (4) The patient who is a pregnant or lactating woman or planning to become pregnant; (5) Immunomodulators and hormones were taken for at least six months, and antipyretic and analgesic drugs were taken for two weeks; (6) Those considered unsuitable for inclusion by researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depression Scale, HAMD; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hamilton Anxiety Scale, HAMA;Mood Disorder Questionnaire, MDQ;Snaith-Hamilton Pleasure Scale, SHAPS;The Insomnia Severity index, ISI;Self-rating depression scale, SDS;the 21-item Depression Anxiety Stress Scale, DASS-21;Beck Scale for Suicide Ideation-Chinese Version, BSI-CV;Digital span test, DST;Digit-symbol substitution test, DSST;Visual Analogue Score, VAS;The amplitudeof low-frequency fluctuations, ALFF;Functional connection, FC; | — |
Countries
China
Contacts
Public ContactZang Yufeng
The Affiliated Hospital of Hangzhou Normal University
Outcome results
None listed