Parkinson's disease
Conditions
Interventions
Experimental group:trancranial direct current stimulation
Experimental group:transcranial magnetic stimulation
Control group:sham trancranial direct current stimulation
Health control:Motor cortical excitability is measured by transcranial magnetic stimulation
Sponsors
First Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Age
45 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1.Parkinson's disease meet the recent diagnostic criteria developed by Movement Disorder Society;2.The KPPS score is higher than or equal to 1 point or VAS score of sensory abnormalities is higher than 0 point,and the duration of PD-related pain or sensory abnormalities symptoms is greater than or equal to 1 month;3. Subjects who can complete transcranial magnetic stimulation and transcranial direct current stimulation.
Exclusion criteria
Exclusion criteria: 1. There are cerebral hemorrhage, cerebral infarction, poisoning, trauma and other lesions that can clearly lead to movement disorders; 2. Patients with scalp trauma, infection, tumor, etc. who are not suitable for wearing the instrument; 3. Patients with intracranial hypertension, epilepsy and other contraindications to transcranial magnetic stimulation and transcranial direct current stimulation; 4. Individuals who are old, weak, or unable to cooperate in completing experimental operations; Clear lesions such as cerebral hemorrhage, cerebral infarction, poisoning, and trauma that can lead to Parkinson's symptoms; 5. The results of the Mini-mental State Examination (MMSE) indicate patients with cognitive impairment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| short latency afferent inhibition;long latency afferent inhibition;resting motor threshold;ipsilateral silent period;KING's Parkinson's Disease Pain Scale;visual analogue scale;Movement Disorder Society Unified-Parkinson Disease Rating Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mini-mental state examination;HAMD-17;HAMA;SCOPA-AUT;Non-Motor Symptoms Scale ;The Epworth Sleeping Scale;REM sleep behavior disorder questionnaire—Hong Kong;The Parkinson's Disease Questionnaire;tactile threshold;pain threshold;pain tolerance;finger tapping test ;foot tapping test;integral electromyoelectric value ;root mean square value of electromyoelectric;Parkinson’s Disease Fatigue Scale ;Parkinson’s Disease Fatigue Scale -2;Hoehn and Yahr scale; | — |
Countries
China
Contacts
Public ContactXianwen Chen
The First Affiliated Hospital of Anhui Medical University
Outcome results
None listed