Helicobacter pylori infection
Conditions
Interventions
A:Amoxicillin (1000mg each time, three times a day) + tegoprazan (50mg each time, once a day) for 2 weeks
B:Amoxicillin (1000mg each time, three times a day) + tegoprazan(50mg each time, twice a day) for 2 weeks
C:Amoxicillin (1000mg twice daily)+ clarithromycin (500mg twice daily)+ bismuth (220mg twice daily)+ esomeprazole (20mg twice daily) for 2 weeks
Sponsors
Fujian Provincial Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.Adult patients, aged 18 to 70 years; 2.Patients who did not take antibiotics, bismuth and traditional Chinese medicine 4 weeks before treatment, and patients who took PPI, H2 receptor antagonists and other drugs 2 weeks before treatment; 3.Hp-positive was diagnosed by C13 or C14-urea breath test and rapid urease test; 4.Informed and agreed to participate in the study, patients with complete medical records and follow-up records.
Exclusion criteria
Exclusion criteria: 1.With severe heart, lung, and kidney dysfunction and low immunity; 2.Patients with drug allergy contraindications; 3.Persons with mental illness or communication difficulties; 4.Pregnancy, lactation; 5.Patients with organic diseases such as gastrointestinal tumor and gastrointestinal hemorrhage.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| eradication rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| dverse reaction;antibiotic resistance of Helicobacter pylori;flora;Degree of clinical symptom remission; | — |
Countries
China
Contacts
Public ContactZhihui Lin
Fujian Provincial Hospital
Outcome results
None listed