Renal Chronic Kidney Disease(CKD3?4 )
Conditions
Interventions
Control group:Regular medication + placebo
Experimental group:Regular medication+HMUMSC
Sponsors
Tongji Hospital Tongji Medical College of Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1)Patients with clinical diagnosis of chronic kidney disease (CKD) and stage 3 and stage 4 (GFR 15-60 ml/min) of CKD (American Kidney Disease Foundation stage) (2)Agree to sign the informed consent form at the same time by means of participation of the pilot group (3)Age between 18-65 years old
Exclusion criteria
Exclusion criteria: (1)Patients who are taking immunosuppressants or have been taking them within a month (2)Patients with a 30% increase in creatinine in the past 3 months and who are about to undergo dialysis (3)Suffering from severe heart, respiratory insufficiency, viral hepatitis, and sexually transmitted diseases (4)Hypersensitivity to stem cells themselves or stem cell-related media (5)Patients with recent bacterial, viral, or fungal infections (6)Have a history of tumors or are currently suffering from tumor conditions (7)Pregnant or breastfeeding (8)Have participated in drug-related clinical trials in the past two months (9)Any form of substance abuse, mental illness, and other conditions that researchers believe may affect the effectiveness of the test or the patient's physical health
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| German Federal Republic (GFR); | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of serious adverse events;Immunoglobulin A;Immunoglobulin G;Immunoglobulin M;Complement C3;Complement C4;Type C reactive protein;interleukin-6;Peripheral hemolymocyte subsets;Urine protein;Urine RBC;24-hour urine protei;Urine albumin/creatinine;Electrolytes;Hemoglobin;Albumin;Heart ultrasound;Carotid ultrasound;Amino-terminal pro brain natriuretic peptide;1, 25dihydroxyvitamin D3; | — |
Countries
China
Contacts
Public ContactGang Xu
Tongji Hospital Tongji Medical College of Huazhong University of Science and Technology
Outcome results
None listed