Preoperative sedation
Conditions
Interventions
experimental group DS1:Dexmedetomidine 1ug/kg+ esketamine 0.5mg/kg nasal drops 30min before surgery
experimental group DS2:Dexmedetomidine 1.5ug/kg+ esketamine 0.5mg/kg nasal drops 30min before surgery
experimental group DS3:Dexmedetomidine 2ug/kg+ esketamine 0.5mg/kg nasal drops 30min before surgery
Sponsors
Department of anesthesiology, The Children's Hospital, School of Medicine, Zhejiang University
Eligibility
Sex/Gender
All
Age
2 Years to 6 Years
Inclusion criteria
Inclusion criteria: (1) Age 2-6 years old, gender unlimited; (2) Tonsil/adenoidectomy under sevoflurane anesthesia was performed at selected time, and the operation time was less than 2 hours; (3) ASA grade ? ~ ?; (4) No history of severe upper respiratory tract obstruction; (5) Informed consent signed by the family members of the children;
Exclusion criteria
Exclusion criteria: (1) Allergic to dexmedetomidine or esketamine; (2) Congenital heart disease (tetralogy of Fallot, patent ductus arteriosus, ventricular septal defect, etc.); (3) lung diseases (lung infection, bronchial asthma, etc.); (4) known rhinitis or nasal deformity; (5) growth retardation; (6) diseases of nervous system; (7) Refusing to take medication before nasal drops;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sedation level after 30 minutes of intervention; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time of onset of sedation;Parental separation anxiety score;Mask acceptance score;Recovery time; | — |
Countries
China
Contacts
Public ContactXinna Wu
The Children's Hospital, School of Medicine, Zhejiang University
Outcome results
None listed