Hypertension
Conditions
Interventions
Experimental group:Lifestyle intervention combined with andrographolide
Control group:Lifestyle intervention
Sponsors
The First Affiliated Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Primary hypertension (office blood pressure: systolic blood pressure 130-159 mmHg and/or diastolic blood pressure 80-99 mmHg, meeting the 2018AHA hypertension guidelines diagnostic criteria for grade 1 hypertension) with vascular dysfunction (FMD<5%); 2, 18 to 75 years old; 3. Did not use any drugs or dietary supplements affecting blood pressure and vascular endothelial function in the past 3 months, mainly including antihypertensive, lipid-lowering, glucose-lowering drugs and natural plant extracts antioxidants; 4. Informed consent should be signed after fully understanding the purpose and process of the study, disease characteristics, drug effects, methods of relevant examinations, and potential risks/benefits of the study.
Exclusion criteria
Exclusion criteria: 1. There are secondary blood pressure raising factors; 2. Allergic or intolerant to drugs; 3. Severe heart disease, abnormal liver and kidney function (ALT greater than the upper limit of normal; eGFR < 60 mL/min/1.73 m2), acute and chronic infections, autoimmune diseases, and any history of cancer. 4. Patients with mental illness who cannot cooperate; 5. Pregnant women, lactating women or expectant pregnant women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| brachial-ankle pulse wave velocity;flow-mediated vasodilatation; | — |
Secondary
| Measure | Time frame |
|---|---|
| blood pressure; inflammatory factors;blood biochemistry; | — |
Countries
China
Contacts
Public ContactTao Jun
The First Affiliated Hospital of Sun Yat-sen University
Outcome results
None listed