Parkinson‘s disease
Conditions
Interventions
tACS+MIRT group:tACS+MIRT
sham-tACS+MIRT group:sham-tACS+MIRT
Sponsors
Beijing Rehabilitation Hospital, Capital Medical University, Beijing, China
Eligibility
Sex/Gender
All
Age
45 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria for primary Parkinson's disease (meet the clinical diagnostic criteria for Parkinson's disease issued by the International Society for Movement Disorders in 2015); 2. H-Y stages 1-3; 3. 45-70 years old; 4. The drug effect was stable for more than 2 weeks without adjustment and no DBS operation was performed; 5. Can walk independently without assistance (including accessories).
Exclusion criteria
Exclusion criteria: 1. The diagnosis is unclear or suspected to be Parkinson's syndrome (such as vascular, drug-induced and post-infection Parkinson's syndrome), multi-system atrophy, progressive supranuclear paralysis, etc.; 2. Cognitive, motor, speech and other disorders caused by other neurological diseases; 3. Have a history of epilepsy or other contraindications for transcranial AC stimulation; 4. Patients who are unwilling or unable to participate in MRI examination (claustrophobia); 5. Severe cognitive impairment or audio-visual impairment unable to communicate and cooperate with the examination; 6. Serious diseases such as heart, lung, liver and kidney insufficiency; 7. Can not cooperate with the completion of treatment or examination; Can't sign informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PDQ-39; | — |
Secondary
| Measure | Time frame |
|---|---|
| Motor function assessment;Evaluation of non-motor symptoms;EEG;fMRI;Biomarker;LED changes interval; | — |
Countries
China
Contacts
Public ContactBoyan Fang
Beijing Rehabilitation Hospital,Capital Medical University, Beijing, China
Outcome results
None listed