Effect of acetylcysteine solution for salivary gland lavage on the salivary secretion of patients with Sjogren's syndrome

Salivary gland irrigation relieves dry mouth in patients with Sjogren's syndrome

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300071950

Enrollment

Unknown

Registered

2023-05-30

Start date

2023-06-01

Completion date

Unknown

Last updated

2023-06-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sjögren's syndrome

Interventions

saline:Salivary gland irrigation with physiological saline through the opening of the salivary duct

acetylcysteine solution:Salivary gland irrigation with acetylcysteine solution through the opening of the salivary duct

Blank Control:N/A

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: The patients were aged between 18 to 75 years old, with unstimulated whole saliva flow (UWS) of more than 0.00 mL/min and chewing-stimulated whole saliva flow (SWS) of more than 0.02 mL/min.

Exclusion criteria

Exclusion criteria: Patients with hypertension, diabetes, acute infection of salivary glands, and previous radiotherapy to the head and neck were excluded.

Design outcomes

Primary

Measure	Time frame
Acid stimulates salivary flow;unstimulates salivary flow;Clinical Oral Dryness Score, CODS;	—

Secondary

Measure	Time frame
Xerostomia Inventory, XI;European League Against Rheumatism SS Patient-Reported Index, ESSPRI;	—

Countries

China

Contacts

Public ContactZhen Fu

The Fourth Affiliated Hospital of Nanjing Medical University

25070697@qq.com+86 181 6810 9123

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026