Patients undergoing extracorporeal circulation cardiac surgery
Conditions
Interventions
Hydroxycodone group:Oxycodone is used as an opioid during surgery for anesthesia induction and maintenance
Sufentanil group:Sufentanil is used as an opioid during surgery for anesthesia induction and maintenance
Sponsors
Qilu Hospital of Shandong University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1) Patients undergoing extracorporeal circulation cardiac surgery; 2) ASA is classified as Level II or III; 3) NYHA is classified as Level II or III; 4) Normal preoperative lung function examination; 5) Age<75 years old; 6) No myocardial infarction occurred within the past 3 months; 7) There is no clear history of drug allergy in the past; 8) For the first time undergoing cardiac surgery.
Exclusion criteria
Exclusion criteria: 1) Angiotensin converting enzyme inhibitor therapy; 2) Apply opioid receptor drugs or non steroidal anti-inflammatory drugs and other analgesics 2 weeks before surgery; 3) History of communication barriers or potential psychological illnesses; 4) Severe liver dysfunction (Child Pugh C grade) 5) Severe renal insufficiency (preoperative dialysis)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pulmonary alveolar arterial oxygen partial pressure difference ;C-reactive protein; | — |
Secondary
| Measure | Time frame |
|---|---|
| Plasma Inflammatory Factor Indicators TNF-a;Plasma Inflammatory Factor Indicator IL-6;Plasma Inflammatory Factor Indicator IL-10;Plasma beta arrestin 2;High sensitivity C-reactive protein ;Intraoperative hemodynamic indicators;The use of cardiovascular drugs (number and dosage of drug recommendations);Sedation Index (BIS);Recovery status of patients after extubation (modified Aldrete scoring table);The incidence and timing of postoperative nausea and vomiting in patients; | — |
Countries
China
Contacts
Public ContactYonghao Hou
Qilu Hospital of Shandong University
Outcome results
None listed