Impaired islet function and its relationship with short-term and long-term prognosis in patients with early acute necrotizing pancreatitis: A single-center, prospective, observational study

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2300071907

Enrollment

Unknown

Registered

2023-05-29

Start date

2023-06-01

Completion date

Unknown

Last updated

2023-06-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

acute pancreatitis

Interventions

acute pancreatitis:None

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1.With the diagnosis of acute necrotizing pancreatitis; 2.The first episode of AP, and the onset of abdominal pain to admission was less than one week; 3.Age between 18 to 70 years old; 4. Resumption of oral feeding or enteral nutrition, no obvious gastrointestinal reflux symptoms; 5. Already signed informed consent.

Exclusion criteria

Exclusion criteria: 1.Previous history of diabetes mellitus, HbA1c=6.5% at admission; 2.Pregnant pancreatitis, history of chronic pancreatitis, malignancy related acute pancreatitis; 3.Patients with a known history of severe cardiovascular, respiratory, renal or hepatic diseases; 4.Relative or absolute contraindications to enteral nutrition.

Design outcomes

Primary

Measure	Time frame
Occurrence of infection;Occurrence of PPDM-A;Quality-of-life Score;	—

Secondary

Measure	Time frame
Organ failure-free days;blood glucose;Average daily insulin dosage;In-hospital mortality;Length of Hospital Stay;In-hospital cost;Re-hospitalization for recurrent acute pancreatitis;	—

Countries

China

Contacts

Public ContactZhihui Tong

Jinling Clinical Medical College, Nanjing Medical University

njzyantol@hotmail.com+86 138 5194 8781

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026