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Effect of driving pressure-guided Positive End-Expiratory Pressure titration on respiratory function and oxidative stress in patients undergoing gynaecological laparoscopic surgery

Effect of driving pressure-guided Positive End-Expiratory Pressure titration on respiratory function and oxidative stress in patients undergoing gynaecological laparoscopic surgery

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300071898
Enrollment
Unknown
Registered
2023-05-29
Start date
2023-05-30
Completion date
Unknown
Last updated
2023-06-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

lung injury

Interventions

individual PEEP group:driving pressure-guided individualized Positive End-Expiratory Pressure
Fixed PEEP group:Fixed Positive End-Expiratory Pressure
No PEEP group:No Positive End-Expiratory Pressure

Sponsors

Huaihe Hospital of Henan University
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: 1. Patients scheduled for gynaecological laparoscopic surgery expected to last more than 90min under general anesthesia; 2. Patients aged 45-65 years; 3. ASA I-II status; 4. Body-Mass Index (BMI) 18.5-24.0 kg/m2.

Exclusion criteria

Exclusion criteria: 1. A history of upper respiratory tract or pulmonary infection within the previous 4 weeks; 2. Chronic lung-related diseases; 3. History of chest or lung surgery; 4. Neuromuscular dysfunction; 5. Serious cardiovascular, lung, kidney, or hematopoietic diseases, such as renal failure, leukemia, congenital heart diseases, etc.

Design outcomes

Primary

MeasureTime frame
Indicators of oxidative stress;The parameters of respiratory function;—

Countries

China

Contacts

Public ContactDao Xiang

Huaihe Hospital of Henan University

327291486@qq.com+86 187 3736 0590

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026