Gynecological malignant tumors
Conditions
Interventions
Phosphopofol disodium group:Midazolam 0.2 mg, fopropofol disodium 20-30 mg/kg, sufentanil 0.2-0.4 µg/kg, cis-atracurium 0.2 mg/kg intravenously in the fopropofol disodium group, and the patient's jaw
Sevoflurane group:Under the monitoring of BIS, the sevoflurane group inhaled 8% sevoflurane by tidal volume, causing the patient's consciousness to disappear, adjusted the concentration of inhaled sev
Sponsors
Affiliated Hospital of Zunyi Medical University
Eligibility
Sex/Gender
All
Age
20 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Age greater than 20 years old and less than 70 years old 2. Surgical surgery for gynecological malignant tumors (cervical cancer, ovarian cancer and endometrial cancer) under general anesthesia 3. ASA grade I.~III 4. Sign the informed consent form
Exclusion criteria
Exclusion criteria: 1. Patients refuse to participate in clinical trials 2. Have a history of cancer before 3. Allergic to phosphopofol disodium or sevoflurane 4. Plan to perform other surgeries at the same time 5. Preoperative co-infection 6. Suspicious or diagnosed malignant hyperthermia history by himself or family members 7. Serious cardiovascular diseases (severe arrhythmia, acute coronary syndrome, acute and chronic heart failure) 8. Liver and kidney function are obviously abnormal 9. Have neuromuscular junction diseases (such as myasthenia gravis), or have used antibiotics that may affect neuromuscular conduction function (such as aminoglycoside antibiotics) 10. Those who undergo simple biopsy and palliative surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Levels of circulating natural killer T cells, type 1 and type 17 helper T cells, and cytotoxic T cells in peripheral venous blood.; | — |
Secondary
| Measure | Time frame |
|---|---|
| The proportion of CD4 and CD25 expression in circulating regulatory T cells, and the proportion of circulating neutrophils, lymphocytes, and monocytes; | — |
Countries
China
Contacts
Public ContactHaiying Wang
Affiliated Hospital of Zunyi Medical University
Outcome results
None listed